To precisely regulate the release of medicine throughout the gastrointestinal system, many types of oral dosage forms can be used. Matrix systems and coated dose forms are examples of this (eg tablets, capsules, and pellets). However, providing a desirable release profile for a specific medicine at a given dose might be extremely difficult.
The workshop on oral controlled release (OCR) was organized by The APGI (Association de Pharmacie Galénique Industrielle). The objective of this workshop was to provide a focus for disseminating, discussing, and exchanging information related to oral controlled release technology relevant to both academia and industry. This would facilitate the development of new ideas and accelerate innovation.
The Workshop
The workshop on OCR was organized by The APGI (Association de Pharmacie Galénique Industrielle).The objective(s) of this workshop was to provide a focused platform for dissemination, discussion, and exchange of information related to OCR technology relevant to both academia and industry, which will facilitate the development of new ideas and accelerate innovation.
An OCR system allows medicine to be released within the GI tract over a period of time:
- It is made of biocompatible material.
- It retains the properties of the active ingredient through its lifetime.
- It has a drug loading capacity as well as a drug release mechanism.
- It can easily use by carrying only some drug manufacturing process.
Controlled Release Of Medicine, Concept, And Classification
Controlled release drug delivery is a technique for extending the duration of action of medications in order to achieve more efficient control of their effects. The main objective is to provide continuous therapeutic levels of medicines over an extended period. Controlled release dosage forms can be used to improve patient compliance, reduce side effects, and lower overall costs. Controlled Release Drug Delivery System (CRDDS) is a technology that allows for the administration on multiple time scales with temporal control offering advantages over conventional formulations such as tablets or capsules which deliver all active ingredients at once.
Compartmental Approach, Mathematical Modeling Of Drug Release
The drug release is considered as an event that occurs in a compartmental approach, which is a volume of fluid that can be subdivided into a series of smaller volumes called “compartments”. The rate at which the drug enters each compartment is proportional to its surface area. The total amount of drug released depends on both the number and size of compartments.
In mathematical modeling, we assume that the rate at which a substance leaves a system equals its concentration gradient across this system (i.e., if there are more molecules on one side than another).
Final Notes
OCR is a new research area in the field of pharmaceutical sciences and is growing rapidly. A great need exists to develop easy-to-administer oral dosage forms with improved therapeutic index and bioavailability, reduced side effects, and toxicity. This workshop aims to provide an overview of the current trends in Oral Controlled Release (OCR) systems, their design strategies, and evaluation techniques.